{"id":15458,"date":"2026-07-28T09:43:39","date_gmt":"2026-07-28T09:43:39","guid":{"rendered":"https:\/\/glabridin.net\/?p=15458"},"modified":"2026-07-28T09:45:39","modified_gmt":"2026-07-28T09:45:39","slug":"what-is-stearyl-glycyrrhetinate-technical-brief-anti-inflammatory-data-and-formulating-oil-soluble-licorice-derivatives","status":"publish","type":"post","link":"https:\/\/glabridin.net\/ko\/what-is-stearyl-glycyrrhetinate-technical-brief-anti-inflammatory-data-and-formulating-oil-soluble-licorice-derivatives\/","title":{"rendered":"\uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8\ub780 \ubb34\uc5c7\uc778\uac00\uc694? \uae30\uc220 \uac1c\uc694, \ud56d\uc5fc\uc99d \ub370\uc774\ud130, \uc624\uc77c \uac00\uc6a9\uc131 \uac10\ucd08 \uc720\ub3c4\uccb4 \uc81c\ud615\ud654"},"content":{"rendered":"
\n\n

\n \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8<\/a><\/strong> \uc740 18\u03b2-\uae00\ub9ac\uc2dc\ub808\ud2f4\uc0b0\uacfc \uc2a4\ud14c\uc544\ub9b4 \uc54c\ucf54\uc62c\uc5d0\uc11c \uc720\ub798\ud55c \uce5c\uc720\uc131 \uc5d0\uc2a4\ud14c\ub974\uc785\ub2c8\ub2e4. \uc218\uc6a9\uc131 \uac10\ucd08 \ucd94\ucd9c\ubb3c\uc778 \ub514\ud3ec\ud0c0\uc298 \uae00\ub9ac\uc2dc\ub9ac\uc81c\uc774\ud2b8\uac00 \uc218\uc131 \uc138\ub7fc\uc5d0\uc11c \uc6b0\uc138\ud558\uc9c0\ub9cc, \uc18c\uc218\uc131 \uac01\uc9c8\uce35\uc744 \ud1b5\uacfc\ud558\ub294 \ub370 \uc5b4\ub824\uc6c0\uc744 \uacaa\uc2b5\ub2c8\ub2e4. \uae00\ub9ac\uc2dc\ub808\ud2f4\uc0b0\uc5d0 C18 \uc9c0\ubc29 \uc0ac\uc2ac\uc744 \uc5d0\uc2a4\ud14c\ub974\ud654\ud558\uba74 \uc774\ub7ec\ud55c \ud55c\uacc4\uac00 \ud574\uacb0\ub429\ub2c8\ub2e4. \uadf8 \uacb0\uacfc \ubb34\uc218 \uc2dc\uc2a4\ud15c, \uc5d0\uba40\uc83c \ubc0f \uc9c0\uc9c8 \uc7a5\ubcbd \ubcf5\uad6c \uc81c\ud615\uc744 \uc704\ud574 \uc124\uacc4\ub41c \uc9c0\uc9c8 \ud638\ud658 \ud65c\uc131 \uc131\ubd84\uc774 \ub9cc\ub4e4\uc5b4\uc9d1\ub2c8\ub2e4.\n <\/p>\n\n

\n\n

\n \ud654\ud559\uc801 \ud2b9\uc131 \ubc0f \ubd84\uc790 \uad6c\uc870\n <\/h2>\n\n
    \n
  • INCI \uba85\uce6d:<\/strong> \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8<\/li>\n
  • CAS \ubc88\ud638:<\/strong> 13832-70-7<\/span><\/li>\n
  • EINECS\/ELINCS \ubc88\ud638:<\/strong> 419-580-5<\/span><\/li>\n
  • \ubd84\uc790\uc2dd:<\/strong> C48H82O4<\/li>\n
  • Molecular Weight:<\/strong> 16 g\/mol<\/li>\n
  • \ud654\ud559 \uad6c\uc870:<\/strong> 18\u03b2-\uae00\ub9ac\uc2dc\ub808\ud2f4\uc0b0 30-\uc2a4\ud14c\uc544\ub9b4 \uc5d0\uc2a4\ud14c\ub974<\/li>\n <\/ul>\n\n
    \n CH3 CH3
    \n | |
    \n [ \uae00\ub9ac\uc2dc\ub808\ud2f4\uc0b0 \ucf54\uc5b4 ] \u2014 C(=O)\u2014O\u2014(CH2)17\u2014CH3
    \n |
    \n O=C\n <\/div>\n\n

    \n \ucc9c\uc5f0 18\u03b2-\uae00\ub9ac\uc2dc\ub808\ud2f4\uc0b0\uc740 C-30 \uc704\uce58\uc5d0 \uce74\ub974\ubcf5\uc2e4\uc0b0 \uadf8\ub8f9\uc744 \ud3ec\ud568\ud569\ub2c8\ub2e4. \uc625\ud0c0\ub370\uce78\uc62c(\uc2a4\ud14c\uc544\ub9b4 \uc54c\ucf54\uc62c)\ub85c C-30\uc5d0\uc11c \uc5d0\uc2a4\ud14c\ub974\ud654\ud558\uba74 \uce5c\uc720\uc131(Log P = 6.2<\/span>)\uc774 \uc99d\uac00\ud569\ub2c8\ub2e4. \uc774 \ubcc0\ud654\ub294 \ud45c\ud53c \uac04 \uc9c0\uc9c8\uc744 \ud1b5\uacfc\ud558\ub294 \uac83\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4. \uac01\uc9c8\uce35 \ub0b4\ubd80\uc5d0 \ub4e4\uc5b4\uac00\uba74 \ub0b4\uc778\uc131 \uc5d0\uc2a4\ud14c\ub77c\uc81c\uac00 \uc5d0\uc2a4\ud14c\ub974 \uacb0\ud569\uc744 \uc810\uc9c4\uc801\uc73c\ub85c \ubd84\ud574\ud558\uc5ec \uc720\ub9ac \uae00\ub9ac\uc2dc\ub808\ud2f4\uc0b0\uc744 \ubc29\ucd9c\ud558\uc5ec \uc9c0\uc18d\uc801\uc778 \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \ub098\ud0c0\ub0c5\ub2c8\ub2e4.\n <\/p>\n\n

    \n \ud45c\uc900 \ubd84\uc11d \uc99d\uba85\uc11c(COA) \uc0ac\uc591\n <\/h2>\n\n

    \ub2e4\uc74c \ud45c\ub294 \ud654\uc7a5\ud488 \uc81c\uc870\ub97c \uc704\ud55c \uc0b0\uc5c5\uc6a9 \uc6d0\ub8cc \ud488\uc9c8 \uad00\ub9ac \uae30\uc900\uc744 \uc694\uc57d\ud55c \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n

    \n \n \n \n \n \n \n \n \n \n \n \n \n \n
    \uc2dc\ud5d8 \ud56d\ubaa9<\/th>\n \uc0ac\uc591 \ud45c\uc900<\/th>\n Typical Batch Result<\/th>\n \ud14c\uc2a4\ud2b8 \ubc29\ubc95<\/th>\n <\/tr>\n <\/thead>\n
    \ubaa8\uc2b5<\/td>\n \ud770\uc0c9 \ub610\ub294 \ubbf8\uc0c9\uc758 \uacb0\uc815\uc131 \ubd84\ub9d0<\/td>\n \ud770\uc0c9 \ubbf8\uc138 \ubd84\ub9d0<\/td>\n \uc721\uc548 \uac80\uc0ac<\/td>\n <\/tr>\n
    \ub0c4\uc0c8<\/td>\n \ud2b9\uc720\uc758 \ud76c\ubbf8\ud55c \ub0c4\uc0c8<\/td>\n \uc801\ud569<\/td>\n \ud6c4\uac01<\/td>\n <\/tr>\n
    \uc21c\ub3c4 (HPLC \ubd84\uc11d)<\/td>\n \u2265 98.0%<\/td>\n 6%<\/td>\n HPLC (C18 \uceec\ub7fc, UV 254 nm)<\/td>\n <\/tr>\n
    \ub179\ub294\uc810<\/td>\n 0 \u00b0C \u2013 77.0 \u00b0C<\/td>\n 5 \u00b0C \u2013 75.0 \u00b0C<\/td>\n \ubaa8\uc138\uad00 \uc735\uc810 \uce21\uc815\uae30<\/td>\n <\/tr>\n
    \uac74\uc870 \uac10\ub7c9<\/td>\n \u2264 1.0%<\/td>\n 3%<\/td>\n 105 \u00b0C, 2\uc2dc\uac04<\/td>\n <\/tr>\n
    \uc810\ud654 \uc794\ub958\ubb3c<\/td>\n \u2264 0.2%<\/td>\n 0.08%<\/td>\n 600 \u00b0C\uc5d0\uc11c \uc810\ud654<\/td>\n <\/tr>\n
    \uc911\uae08\uc18d(\ub0a9 \uae30\uc900)<\/td>\n 10ppm \uc774\ud558<\/td>\n 5 ppm \ubbf8\ub9cc<\/td>\n ICP-MS<\/td>\n <\/tr>\n
    \ube44\uc18c(As)<\/td>\n \u2264 2 ppm<\/td>\n 1 ppm \ubbf8\ub9cc<\/td>\n AAS<\/td>\n <\/tr>\n
    \ubbf8\uc0dd\ubb3c \uc2dc\ud5d8<\/td>\n \ucd1d \uade0\uc218 < 100 CFU\/g<\/td>\n < 10 CFU\/g<\/td>\n ISO 21149 \/ ISO 16212<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n

    \n \uc6a9\ud574\ub3c4 \ud504\ub85c\ud544 \ubc0f \uc6a9\ub9e4 \ud638\ud658\uc131\n <\/h2>\n\n

    \n \uae00\ub9ac\uc2dc\ub9ac\uc9c4\uc0b0\uc758 \uc5fc \ud615\ud0dc\uc640 \ub2ec\ub9ac \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8\ub294 \ubb3c\uc5d0 \uac70\uc758 \ub179\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4(20 \u00b0C\uc5d0\uc11c 9 \u03bcg\/L<\/span>). \uc6a9\ud574\ub41c \uc9c0\uc9c8 \uc6b4\ubc18\uccb4 \ub610\ub294 \ub530\ub73b\ud55c \uc720\uae30 \uc6a9\ub9e4\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.\n <\/p>\n\n

    \n \n \n \n \n \n \n \n \n \n \n
    \uc6a9\ub9e4 \/ \uc624\uc77c \uc0c1<\/th>\n 25 \u00b0C\uc5d0\uc11c\uc758 \uc6a9\ud574\ub3c4<\/th>\n 75 \u00b0C\uc5d0\uc11c\uc758 \uc6a9\ud574\ub3c4<\/th>\n \uc81c\ud615 \ucc38\uace0 \uc0ac\ud56d<\/th>\n <\/tr>\n <\/thead>\n
    \ubb3c<\/td>\n Insoluble<\/td>\n Insoluble<\/td>\n \uc9c1\uc811\uc801\uc778 \uc218\uc131 \uc0c1\uc5d0\ub294 \ubd80\uc801\ud569<\/td>\n <\/tr>\n
    \uc5d0\ud0c4\uc62c (95%)<\/td>\n \uc57d\uac04 \uc6a9\ud574\ub428<\/td>\n \uc6a9\ud574\ub428 (~2.5%)<\/td>\n \uc21c\uc218\ud55c \uc0c1\ud0dc\uc5d0\uc11c \ube60\ub974\uac8c \ub0c9\uac01\ud558\uba74 \uce68\uc804\ub428<\/td>\n <\/tr>\n
    \uce74\ud504\ub9b4\uc0b0\/\uce74\ud504\ub974\uc0b0 \ud2b8\ub9ac\uae00\ub9ac\uc138\ub77c\uc774\ub4dc (MCT)<\/td>\n ~0.8% w\/w<\/td>\n > 5.0% w\/w<\/td>\n \uc0ac\uc804 \uc6a9\ud574\ub97c \uc704\ud55c \uc774\uc0c1\uc801\uc778 \uc6b4\ubc18 \uc624\uc77c<\/td>\n <\/tr>\n
    \uc2a4\ucfe0\uc54c\ub780<\/td>\n ~0.5% w\/w<\/td>\n > 4.0% w\/w<\/td>\n \ud398\uc774\uc15c \uc624\uc77c\uc744 \uc704\ud55c \uc6b0\uc218\ud55c \uc9c0\uc9c8 \ubca0\uc774\uc2a4<\/td>\n <\/tr>\n
    \ubbf8\ub124\ub784 \uc624\uc77c \/ \uc774\uc18c\ud5e5\uc0ac\ub370\uce78<\/td>\n ~0.4% w\/w<\/td>\n ~3.5% w\/w<\/td>\n \ud0c4\ud654\uc218\uc18c \uc2dc\uc2a4\ud15c\uc5d0\uc11c \uc88b\uc740 \ud638\ud658\uc131<\/td>\n <\/tr>\n
    \ud638\ud638\ubc14 \uc624\uc77c \/ \uc2dd\ubb3c\uc131 \uc624\uc77c<\/td>\n ~0.3% w\/w<\/td>\n > 3.0% w\/w<\/td>\n \uc6a9\ud574\ub97c \uc704\ud574 75 \u00b0C \uc774\uc0c1\uc73c\ub85c \uac00\uc5f4\ud574\uc57c \ud568<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n

    \n \uc0dd\ubb3c\ud559\uc801 \uba54\ucee4\ub2c8\uc998 \ubc0f \uc2dc\ud5d8\uad00 \ub0b4 \uc131\ub2a5 \ub370\uc774\ud130\n <\/h2>\n\n

    \n \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8\ub294 \uc8fc\ub85c 11\u03b2-\ud558\uc774\ub4dc\ub85d\uc2dc\uc2a4\ud14c\ub85c\uc774\ub4dc \ud0c8\uc218\uc18c\ud6a8\uc18c \uc720\ud615 1(11\u03b2-HSD1) \ubc0f \ud558\ub958 \uc544\ub77c\ud0a4\ub3c8\uc0b0 \uacbd\ub85c\ub97c \uc5b5\uc81c\ud558\uc5ec \uc5fc\uc99d \uce90\uc2a4\ucf00\uc774\ub4dc\ub97c \uc870\uc808\ud569\ub2c8\ub2e4.\n <\/p>\n\n

    \uc5fc\uc99d \uc720\ubc1c \ub9e4\uac1c\uccb4 \uc5b5\uc81c<\/h3>\n

    \n \uc5fc\uc99d \uc2a4\ud2b8\ub808\uc2a4 \uc694\uc778(\uc790\uc678\uc120, \ud654\ud559\uc801 \uc790\uadf9\uc81c, \uacc4\uba74\ud65c\uc131\uc81c \ud30c\uad34)\uc740 \ud3ec\uc2a4\ud3ec\ub9ac\ud30c\uc544\uc81c A2\ub97c \ud65c\uc131\ud654\ud569\ub2c8\ub2e4. \uc774 \ud6a8\uc18c\ub294 \uc544\ub77c\ud0a4\ub3c8\uc0b0\uc744 \ubc29\ucd9c\ud558\uc5ec \uc0ac\uc774\ud074\ub85c\uc625\uc2dc\uac8c\ub098\uc81c-2(COX-2)\ub97c \ud1b5\ud574 \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518 E2(PGE2)\ub85c \uc804\ud658\ud569\ub2c8\ub2e4.\n <\/p>\n\n

    \n

    HaCaT \uc138\ud3ec \ubc30\uc591 \ubd84\uc11d (LPS 1 \u03bcg\/mL\ub85c \uc790\uadf9):<\/p>\n

      \n
    • PGE2 \uc5b5\uc81c:<\/strong> IC50 \uac12 4 \u03bcM<\/span> (\ub514\ud3ec\ud0c0\uc298 \uae00\ub9ac\uc2dc\ub9ac\uc81c\uc774\ud2b8\uc758 28.6 \u03bcM \ub300\ube44).<\/li>\n
    • \uc778\ud130\ub8e8\ud0a8-6 (IL-6):<\/strong> IL-6 \ubd84\ube44\ub97c \uac10\uc18c\uc2dc\ud0b4 2%<\/span> 20 \u03bcM\uc5d0\uc11c.<\/li>\n
    • TNF-\u03b1:<\/strong> \ubc1c\ud604\uc744 \uc5b5\uc81c\ud568 8%<\/span> 20 \u03bcM\uc5d0\uc11c.<\/li>\n <\/ul>\n <\/div>\n\n

      \ud56d\uade0 \ubca4\uce58\ub9c8\ud06c (MIC \uac12)<\/h3>\n

      \uad11\ubc94\uc704\ud55c \ud56d\uade0 \ud65c\uc131\uc740 \uc5ec\ub4dc\ub984\uc774 \uc0dd\uae30\uae30 \uc26c\uc6b4 \ud53c\ubd80\uc640 \uc190\uc0c1\ub41c \ud53c\ubd80 \ubbf8\uc0dd\ubb3c\ucd1d\uc744 \uc548\uc815\ud654\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub429\ub2c8\ub2e4. \ud45c\uc900 \uc561\uccb4 \ud76c\uc11d\ubc95 \uc2dc\ud5d8\uc740 \ub2e4\uc74c\uc758 \ucd5c\uc18c \uc5b5\uc81c \ub18d\ub3c4(MIC)\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n

        \n
      • Cutibacterium acnes (ATCC 6919):<\/strong> MIC = 62.5 \u03bcg\/mL<\/span><\/li>\n
      • Staphylococcus aureus (ATCC 6538):<\/strong> MIC = 125 \u03bcg\/mL<\/span><\/li>\n
      • Staphylococcus epidermidis (ATCC 12228):<\/strong> MIC = 250 \u03bcg\/mL<\/span><\/li>\n <\/ul>\n\n

        \uc0dd\uccb4 \ub0b4 \ud64d\ubc18 \uac10\uc18c \uc5f0\uad6c<\/h3>\n

        \n \ubb34\uc791\uc704 \ubd84\ud560 \uc5bc\uad74 \uc784\uc0c1 \uc2dc\ud5d8\uc740 \ub77c\uc6b0\ub9b4 \ud669\uc0b0\ub098\ud2b8\ub968(SLS, 2% \ud328\uce58) \uc790\uadf9 \ud6c4 \ud64d\ubc18 \uac10\uc18c\ub97c \uce21\uc815\ud588\uc2b5\ub2c8\ub2e4. 20\uba85\uc758 \ud53c\ud5d8\uc790\uac00 0.2% \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8 \ud568\uc720 \uc81c\ud615\uacfc \uc704\uc57d \ucc28\ub7c9\uc744 \ud558\ub8e8 \ub450 \ubc88 \uc801\uc6a9\ud588\uc2b5\ub2c8\ub2e4.\n <\/p>\n \n

        \n
          \n
        • 3\uc77c\ucc28:<\/strong> \ud53c\ubd80 \ubd89\uc5b4\uc9d0\uc774 \uac10\uc18c\ud568 4%<\/strong> \uae30\uc900\uc120 \ub300\ube44 (\ubd84\uad11\uad11\ub3c4\uacc4 a* \uac12\uc73c\ub85c \uce21\uc815).<\/li>\n
        • 7\uc77c\ucc28:<\/strong> \ubd89\uc5b4\uc9d0\uc774 \uac10\uc18c\ud568 9%<\/strong>, \uacbd\ud53c \uc218\ubd84 \uc190\uc2e4(TEWL) \ud68c\ubcf5 42% \ub354 \ube60\ub984<\/strong> \uc704\uc57d \uadf8\ub8f9\ubcf4\ub2e4.<\/li>\n <\/ul>\n <\/div>\n\n

          \n \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8 \uc81c\ud615\ud654\n <\/h2>\n\n

          \n \uc804\ud1b5\uc801\uc778 \uac10\ucd08 \uc5fc \ub300\uc2e0 \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8\ub97c \uc120\ud0dd\ud558\ub294 \uc774\uc720\ub294 \ubb34\uc5c7\uc785\ub2c8\uae4c? \ub514\ud3ec\ud0c0\uc298 \uae00\ub9ac\uc2dc\ub9ac\uc81c\uc774\ud2b8\uc640 \uac19\uc740 \uc774\uc628\uc131 \uc5fc\uc758 \uace0\ub18d\ub3c4\ub294 \uc5d0\uba40\uc83c \uc2dc\uc2a4\ud15c\uc744 \ubd88\uc548\uc815\ud558\uac8c \ud558\uac70\ub098 \ud3f4\ub9ac\uba38 \uc99d\uc810\uc81c(\uce74\ubcf4\uba38 \ub610\ub294 \uc544\ud06c\ub9b4\ub808\uc774\ud2b8\/C10-30 \uc54c\ud0ac \uc544\ud06c\ub9b4\ub808\uc774\ud2b8 \ud06c\ub85c\uc2a4\ud3f4\ub9ac\uba38 \ub4f1)\ub97c \ud30c\uad34\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8\ub294 \ube44\uc774\uc628\uc131\uc774\uba70 \uce5c\uc720\uc131\uc774\ubbc0\ub85c \uc5d0\uba40\uc83c \uc810\ub3c4\uc5d0 \uc644\uc804\ud788 \uc911\uc131\uc785\ub2c8\ub2e4.\n <\/p>\n\n

          \uc0c1 \ucc98\ub9ac \ubc0f \uac00\uc5f4 \uc694\uad6c \uc0ac\ud56d<\/h3>\n
            \n
          1. \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8\ub97c \uadf9\uc131 \ub610\ub294 \uc911\uac04 \uadf9\uc131 \uc624\uc77c \uc0c1(MCT, C12-15 \uc54c\ud0ac \ubca4\uc870\uc5d0\uc774\ud2b8 \ub610\ub294 \uc2a4\ucfe0\uc54c\ub780)\uc5d0 \uc9c1\uc811 \ucca8\uac00\ud569\ub2c8\ub2e4.<\/li>\n
          2. \uc624\uc77c \uc0c1\uc744 \uac00\uc5f4\ud569\ub2c8\ub2e4. 75 \u00b0C \u2013 80 \u00b0C<\/strong> \ubd84\ub9d0\uc774 \uc644\uc804\ud788 \uc6a9\ud574\ub418\uc5b4 \ud22c\uba85\ud55c \uc561\uccb4\uac00 \ub420 \ub54c\uae4c\uc9c0 \uc911\uac04 \uc815\ub3c4\uc758 \uad50\ubc18 \ud558\uc5d0.<\/li>\n
          3. \ub3d9\uc77c\ud55c \uc628\ub3c4\uc5d0\uc11c \uc218\uc131 \uc0c1\uacfc \uc5d0\uba40\uc83c\uc744 \uc218\ud589\ud569\ub2c8\ub2e4.<\/li>\n
          4. \ube60\ub974\uac8c \ub0c9\uac01\ud558\ub294 \uacbd\uc6b0, 45 \u00b0C \uc774\ud558\uc5d0\uc11c \uc7ac\uacb0\uc815\ud654\ub97c \ubc29\uc9c0\ud558\uae30 \uc704\ud574 \uc624\uc77c \uc0c1\uc5d0 \ucda9\ubd84\ud55c \uc6a9\ud574 \uc5d0\uc2a4\ud14c\ub974\uac00 \uc788\ub294\uc9c0 \ud655\uc778\ud558\uc2ed\uc2dc\uc624.<\/li>\n <\/ol>\n\n

            \uad8c\uc7a5 \uc6a9\ub7c9 \ub9e4\ud2b8\ub9ad\uc2a4<\/h3>\n
            \n \n \n \n \n \n \n \n \n \n
            \uc801\uc6a9 \uc720\ud615<\/th>\n \uad8c\uc7a5 \uc0ac\uc6a9 \uc218\uc900<\/th>\n \uc8fc\uc694 \uae30\ub2a5<\/th>\n <\/tr>\n <\/thead>\n
            \uc7a5\ubcbd \ubcf5\uad6c \ud06c\ub9bc \ubc0f \ubc24<\/td>\n 1% \u2013 0.5%<\/td>\n \uc9c4\uc815, \uc548\ud2f0 \ub808\ub4dc\ub2c8\uc2a4, \uc9c0\uc9c8 \ubcf4\ucda9<\/td>\n <\/tr>\n
            \ub9bd\ubc24 \ubc0f \ub9bd\uc2a4\ud2f1<\/td>\n 2% \u2013 1.0%<\/td>\n \uac08\ub77c\uc9c4 \uc785\uc220 \ubcf5\uad6c, \ud56d\uc5fc\uc99d \uc9c0\uc6d0<\/td>\n <\/tr>\n
            \uc120\ud06c\ub9bc \ubc0f \uc560\ud504\ud130 \uc120 \ucf00\uc5b4<\/td>\n 1% \u2013 0.3%<\/td>\n UV \uc720\ubc1c \ud64d\ubc18 \uc644\ud654<\/td>\n <\/tr>\n
            \ubb34\uc218 \uc138\ub7fc \ubc0f \ud398\uc774\uc15c \uc624\uc77c<\/td>\n 05% \u2013 0.2%<\/td>\n \ubbfc\uac10\uc131 \ud53c\ubd80\uc758 \uc77c\uc0c1 \uc9c4\uc815<\/td>\n <\/tr>\n
            \uc5ec\ub4dc\ub984 \ubc0f \ubfb0\ub8e8\uc9c0 \uc2a4\ud31f \ud2b8\ub9ac\ud2b8\uba3c\ud2b8<\/td>\n 2% \u2013 0.5%<\/td>\n \uad6d\uc18c \uc5fc\uc99d \uad6c\uc9c4 \uac10\uc18c<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n

            \uc2dc\ub108\uc9c0 \ud65c\uc131 \uc870\ud569<\/h3>\n
              \n
            • \ube44\uc0ac\ubcf4\ub864 (0.2%) + \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8 (0.1%):<\/strong> 5-LOX \ubc0f COX-2 \uacbd\ub85c \ubaa8\ub450\uc758 \uacb0\ud569 \uc5b5\uc81c.<\/li>\n
            • \uc138\ub77c\ub9c8\uc774\ub4dc NP (0.1%) + \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8 (0.2%):<\/strong> \uc138\ud3ec \uac04 \uc9c0\uc9c8\uc744 \uc7ac\uac74\ud558\uba74\uc11c \uc544\uae09\uc131 \uc7a5\ubcbd \uc5fc\uc99d\uc744 \uc904\uc785\ub2c8\ub2e4.<\/li>\n
            • \ud1a0\ucf54\ud398\ub864 (0.5%) + \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8 (0.1%):<\/strong> \uc0b0\ud654\ub85c\ubd80\ud130 \uce5c\uc720\uc131 \ud65c\uc131 \uc131\ubd84\uc744 \ubcf4\ud638\ud558\uba74\uc11c \ud53c\ubd80\uc758 \uc2a4\ucfe0\uc54c\ub80c \uacfc\uc0b0\ud654\ub97c \ubc29\uc9c0\ud569\ub2c8\ub2e4.<\/li>\n <\/ul>\n\n

              \n \ube44\uad50 \ubd84\uc11d: \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8 \ub300 \ub514\ud3ec\ud0c0\uc298 \uae00\ub9ac\uc2dc\ub9ac\uc81c\uc774\ud2b8\n <\/h2>\n\n
              \n \n \n \n \n \n \n \n \n \n \n
              \ud2b9\uc131<\/th>\n \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8<\/th>\n \ub514\uce7c\ub968 \uae00\ub9ac\uc2dc\ub9ac\uc81c\uc774\ud2b8<\/th>\n <\/tr>\n <\/thead>\n
              \uc6a9\ud574\ub3c4<\/td>\n \uc624\uc77c \uc6a9\ud574\uc131 \/ \uce5c\uc720\uc131<\/td>\n \uc218\uc6a9\uc131 \/ \uce5c\uc218\uc131<\/td>\n <\/tr>\n
              Log P \uac12<\/td>\n 6.2<\/td>\n < -1.5<\/td>\n <\/tr>\n
              \ud53c\ubd80 \uce68\ud22c \ud45c\uc801<\/td>\n \uac01\uc9c8\uce35 \ubc0f \uc9c0\uc9c8 \ub9e4\ud2b8\ub9ad\uc2a4<\/td>\n \ud45c\ud53c \uc218\uc131 \uc138\ud3ec \uac04 \uacf5\uac04<\/td>\n <\/tr>\n
              \uc810\ub3c4\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5<\/td>\n \uc5d0\uba40\uc83c \uc720\ubcc0\ud559\uc5d0 \uc601\ud5a5 \uc5c6\uc74c<\/td>\n \uce74\ubcf4\uba38\/\uc824 \uc810\ub3c4\ub97c 0.5% \uc774\uc0c1\uc5d0\uc11c \ub0ae\ucd9c \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/td>\n <\/tr>\n
              \uc5f4 \uc548\uc815\uc131<\/td>\n \uc624\uc77c \uc0c1\uc5d0\uc11c \ucd5c\ub300 85\u00b0C\uae4c\uc9c0 \uc548\uc815\ud569\ub2c8\ub2e4.<\/td>\n \uc218\uc131 \uc0c1\uc5d0\uc11c \ucd5c\ub300 80\u00b0C\uae4c\uc9c0 \uc548\uc815\ud569\ub2c8\ub2e4.<\/td>\n <\/tr>\n
              \uc774\uc0c1\uc801\uc778 \uc81c\ud488 \uc81c\ud615<\/td>\n \ub9bd\uc2a4\ud2f1, \ub9ac\uce58 \ud06c\ub9bc, \uc624\uc77c, \uc120\uc2a4\ud06c\ub9b0<\/td>\n \ud1a0\ub108, \uc824, \uc2dc\ud2b8 \ub9c8\uc2a4\ud06c, \uc218\uc131 \uc138\ub7fc<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n

              \n \uaddc\uc81c \ud604\ud669 \ubc0f \uc548\uc804\uc131 \ud3c9\uac00\n <\/h2>\n\n
                \n
              • \ubbf8\uad6d CIR (\ud654\uc7a5\ud488 \uc131\ubd84 \uac80\ud1a0):<\/strong> \ucd5c\ub300 ~\uae4c\uc9c0 \ud654\uc7a5\ud488 \uc81c\ud615\uc5d0 \uc0ac\uc6a9\ud558\uae30\uc5d0 \uc548\uc804\ud558\ub2e4\uace0 \ud3c9\uac00\ub428 1.0%<\/span>.<\/li>\n
              • EU SCCS \/ CosIng:<\/strong> \ud2b9\uc815 \uc81c\ud55c \uc5c6\uc774 \ub4f1\uc7ac\ub428 (\ucc38\uc870 \ubc88\ud638: 38334); \ud45c\uc900 \ud654\uc7a5\ud488 \uc548\uc804 \ud55c\ub3c4\uac00 \uc801\uc6a9\ub429\ub2c8\ub2e4.<\/li>\n
              • \uc911\uad6d NMPA (IECIC):<\/strong> \uc911\uad6d \uae30\uc874 \ud654\uc7a5\ud488 \uc131\ubd84 \ubaa9\ub85d\uc5d0 \ud3ec\ud568\ub428.<\/li>\n
              • \uc77c\ubcf8 (\uc900\uc758\uc57d\ud488 \ud65c\uc131 \uc131\ubd84):<\/strong> \ud2b9\uc815 \ud55c\ub3c4 \ub0b4\uc5d0\uc11c \ud56d\uc5fc \ubc0f \uc9c4\uc815 \ud6a8\ub2a5\uc5d0 \ub300\ud55c \ud65c\uc131 \uc131\ubd84\uc73c\ub85c \uc2b9\uc778\ub428 (1% \u2013 0.5%<\/span>).<\/li>\n <\/ul>\n\n

                \n \uad11\ub3c5\uc131 \ubc0f \uac10\uc791\uc131 \uc5f0\uad6c\ub294 \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub808\ud2f0\ub124\uc774\ud2b8\uac00 1.0% \ub18d\ub3c4\uc5d0\uc11c \uad11\ub3c5\uc131 \uc7a0\uc7ac\ub825\uc774 \uc5c6\uc74c\uc744 \ud655\uc778\ud569\ub2c8\ub2e4. \ud45c\uc900 \uc778\uccb4 \ubc18\ubcf5 \ud328\uce58 \ud14c\uc2a4\ud2b8(HRIPT)\ub97c \ud1b5\uacfc\ud588\uc73c\uba70 \uc790\uadf9\uc740 \uad00\ucc30\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4.\n <\/p>\n\n

                \n \ud3ec\uc7a5, \ubcf4\uad00 \ubc0f \ucde8\uae09\n <\/h2>\n\n
                  \n
                • \ud3ec\uc7a5:<\/strong> \ud45c\uc900 \uc0b0\uc5c5 \uacf5\uae09\uc740 \uc774\uc911 \ud3f4\ub9ac\uc5d0\ud2f8\ub80c \ubc31\uc73c\ub85c \uc548\uac10\uc744 \ub304 \uc54c\ub8e8\ubbf8\ub284 \ud638\uc77c \ubc31 \ub610\ub294 \uc12c\uc720 \ub4dc\ub7fc\uc73c\ub85c \uc81c\uacf5\ub429\ub2c8\ub2e4.<\/li>\n
                • \ubcf4\uad00 \uc870\uac74:<\/strong> \uc6a9\uae30\ub97c \ubc00\ubd09\ud558\uc5ec \uc11c\ub298\ud558\uace0 \uac74\uc870\ud558\uba70 \ud1b5\ud48d\uc774 \uc798 \ub418\ub294 \uacf3(15\u00b0C \u2013 25\u00b0C)\uc5d0 \ubcf4\uad00\ud558\uc2ed\uc2dc\uc624. \uc9c1\uc0ac\uad11\uc120\uacfc \uc2b5\uae30\ub97c \ud53c\ud558\uc2ed\uc2dc\uc624.<\/li>\n
                • \uc720\ud1b5\uae30\ud55c:<\/strong> \uac1c\ubd09\ud558\uc9c0 \uc54a\uc740 \uc6d0\ub798 \uc6a9\uae30\uc5d0 \ubcf4\uad00 \uc2dc \uc81c\uc870\uc77c\ub85c\ubd80\ud130 24\uac1c\uc6d4.<\/li>\n
                • \uc0d8\ud50c \uc694\uccad:<\/strong> \uc21c\uc218 \ub4f1\uae09 \uc0dd\uc0b0 \uc0d8\ud50c\uc740 \uc694\uccad \uc2dc \uc5f0\uad6c \ubc0f R&D \uc81c\ud615 \uc2dc\ud5d8\uc5d0 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n <\/ul>\n\n
                  \n\n

                  \n \ubb38\ud5cc \ubc0f \uacfc\ud559\uc801 \ucc38\uace0 \ubb38\ud5cc\n <\/h2>\n\n
                    \n
                  1. \ud654\uc7a5\ud488 \uc131\ubd84 \uac80\ud1a0 \uc804\ubb38\uac00 \ud328\ub110. (2007). \uae00\ub9ac\uc2dc\ub808\ud2f4\uc0b0, \uadf8 \uc5fc \ubc0f \uc5d0\uc2a4\ud14c\ub974\uc758 \uc548\uc804\uc131 \ud3c9\uac00 \ucd5c\uc885 \ubcf4\uace0\uc11c<\/em>International Journal of Toxicology, 26(Suppl 2), 79\u2013112.<\/li>\n
                  2. \uc2dc\ubc14\ud0c0, S. (2000). \uac10\ucd08\uc640 \uadf8 \ud65c\uc131 \ud654\ud569\ubb3c\uc758 \ud56d\uc5fc\uc99d \uc791\uc6a9\uc5d0 \ub300\ud55c \uac80\ud1a0<\/em>Journal of the Pharmaceutical Society of Japan, 120(10), 849\u2013862.<\/li>\n
                  3. \ud53c\ub2c8, R. S. H., & \uc11c\uba38\uc2a4, G. F. (1958). \uae00\ub9ac\uc2dc\ub808\ud2f4\uc0b0 \ubc0f \uadf8 \uc720\ub3c4\uccb4\uc758 \ud56d\uc5fc\uc99d \ud65c\uc131<\/em>Journal of Pharmacy and Pharmacology, 10(1), 613\u2013620.<\/li>\n
                  4. \uc694\ucf54\ud0c0, T., \ub2c8\uc2dc\uc624, H., \ucfe0\ubcf4\ud0c0, Y., & \ubbf8\uc870\uad6c\uce58, M. (1998). \uba5c\ub77c\ub2cc \uc0dd\uc131 \ubc0f \uc5fc\uc99d\uc5d0 \ub300\ud55c \uac10\ucd08 \ucd94\ucd9c\ubb3c\uc758 \uc5b5\uc81c \ud6a8\uacfc<\/em>Pigment Cell Research, 11(6), 355\u2013361.<\/li>\n
                  5. \uc774\ub098\uac00\ud0a4, N. \uc678. (2006). 18\u03b2-\uae00\ub9ac\uc2dc\ub808\ud2f4\uc0b0 \uc720\ub3c4\uccb4\uc758 \uc989\uac01\ud615 \ubc0f \uc9c0\uc5f0\ud615 \uacfc\ubbfc \ubc18\uc751 \uc5b5\uc81c \ud6a8\uacfc<\/em>Biological and Pharmaceutical Bulletin, 29(8), 1734\u20131739.<\/li>\n <\/ol>\n\n<\/div>","protected":false},"excerpt":{"rendered":"

                    \uc2a4\ud14c\uc544\ub9b4 \uae00\ub9ac\uc2dc\ub9ac\uc81c\uc774\ud2b8\ub294 \uc2a4\ud14c\uc544\ub9b4 \uc54c\ucf54\uc62c\uacfc 18\u03b2-\uae00\ub9ac\uc2dc\ub808\ud2f4\uc0b0\uc5d0\uc11c \uc720\ub798\ud55c \uce5c\uc720\uc131 \uc5d0\uc2a4\ud14c\ub974\uc785\ub2c8\ub2e4. \uc218\uc131 \uc138\ub7fc\uc5d0\ub294 \ub514\ud3ec\ud0c0\uc298 \uae00\ub9ac\uc2dc\ub9ac\uc81c\uc774\ud2b8\uc640 \uac19\uc740 \uc218\uc6a9\uc131 \uac10\ucd08 \ucd94\ucd9c\ubb3c\uc774 \uc8fc\ub85c \uc0ac\uc6a9\ub418\uc9c0\ub9cc, \uc774\ub7ec\ud55c \ucd94\ucd9c\ubb3c\uc740\u2026<\/p>","protected":false},"author":8,"featured_media":5752,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[60],"tags":[],"class_list":["post-15458","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-product-news"],"yoast_head":"\nWhat Is Stearyl Glycyrrhetinate? 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