{"id":15458,"date":"2026-07-28T09:43:39","date_gmt":"2026-07-28T09:43:39","guid":{"rendered":"https:\/\/glabridin.net\/?p=15458"},"modified":"2026-07-28T09:45:39","modified_gmt":"2026-07-28T09:45:39","slug":"what-is-stearyl-glycyrrhetinate-technical-brief-anti-inflammatory-data-and-formulating-oil-soluble-licorice-derivatives","status":"publish","type":"post","link":"https:\/\/glabridin.net\/es\/what-is-stearyl-glycyrrhetinate-technical-brief-anti-inflammatory-data-and-formulating-oil-soluble-licorice-derivatives\/","title":{"rendered":"\u00bfQu\u00e9 es el Estearil Glicirretinato? Breve T\u00e9cnico, Datos Antiinflamatorios y Formulaci\u00f3n de Derivados de Regaliz Solubles en Aceite"},"content":{"rendered":"
\n\n

\n estearilglicirretinato<\/a><\/strong> es el \u00e9ster lipof\u00edlico derivado del \u00e1cido 18\u03b2-glicirret\u00ednico y el alcohol estear\u00edlico. Si bien los extractos de regaliz solubles en agua como el Glicirrizato Dipot\u00e1sico dominan los sueros acuosos, luchan por penetrar el estrato c\u00f3rneo hidrof\u00f3bico. La esterificaci\u00f3n del \u00e1cido glicirret\u00ednico con una cadena grasa C18 resuelve esta limitaci\u00f3n. El resultado es un ingrediente activo compatible con l\u00edpidos dise\u00f1ado para sistemas anhidros, emulsiones y f\u00f3rmulas de reparaci\u00f3n de la barrera lip\u00eddica.\n <\/p>\n\n

\n\n

\n Perfil Qu\u00edmico y Estructura Molecular\n <\/h2>\n\n
    \n
  • Nombre INCI:<\/strong> estearilglicirretinato<\/li>\n
  • N\u00famero CAS:<\/strong> 13832-70-7<\/span><\/li>\n
  • N\u00famero EINECS\/ELINCS:<\/strong> 419-580-5<\/span><\/li>\n
  • F\u00f3rmula Molecular:<\/strong> C48H82O4<\/li>\n
  • Peso Molecular:<\/strong> 16 g\/mol<\/li>\n
  • Estructura Qu\u00edmica:<\/strong> \u00c9ster 30-estear\u00edlico del \u00e1cido 18\u03b2-glicirret\u00ednico<\/li>\n <\/ul>\n\n
    \n CH3 CH3
    \n | |
    \n [N\u00facleo de \u00c1cido Glicirret\u00ednico] \u2014 C(=O)\u2014O\u2014(CH2)17\u2014CH3
    \n |
    \n O=C\n <\/div>\n\n

    \n El \u00e1cido 18\u03b2-glicirret\u00ednico natural contiene un grupo de \u00e1cido carbox\u00edlico en la posici\u00f3n C-30. La esterificaci\u00f3n en C-30 con octadecanol (alcohol estear\u00edlico) aumenta la lipofilicidad (Log P = 6.2<\/span>). Este cambio facilita el paso a trav\u00e9s de los l\u00edpidos intercelulares epid\u00e9rmicos. Una vez dentro del estrato c\u00f3rneo, las esterasas end\u00f3genas escinden gradualmente el enlace \u00e9ster, liberando \u00e1cido glicirret\u00ednico libre para una actividad biol\u00f3gica sostenida.\n <\/p>\n\n

    \n Especificaciones Est\u00e1ndar del Certificado de An\u00e1lisis (COA)\n <\/h2>\n\n

    La siguiente tabla describe los criterios de control de calidad de las materias primas industriales para la fabricaci\u00f3n de cosm\u00e9ticos:<\/p>\n\n

    \n \n \n \n \n \n \n \n \n \n \n \n \n \n
    Elemento de Prueba<\/th>\n Est\u00e1ndar de Especificaci\u00f3n<\/th>\n Resultado T\u00edpico del Lote<\/th>\n M\u00e9todo de Prueba<\/th>\n <\/tr>\n <\/thead>\n
    Apariencia<\/td>\n Polvo cristalino de color blanco a blanquecino<\/td>\n Polvo fino blanco<\/td>\n Visual inspection<\/td>\n <\/tr>\n
    Olor<\/td>\n Olor d\u00e9bil caracter\u00edstico<\/td>\n Conforme<\/td>\n Olfativo<\/td>\n <\/tr>\n
    Pureza (An\u00e1lisis por HPLC)<\/td>\n \u2265 98.0%<\/td>\n 6%<\/td>\n HPLC (columna C18, UV 254 nm)<\/td>\n <\/tr>\n
    Punto de fusi\u00f3n<\/td>\n 0 \u00b0C \u2013 77.0 \u00b0C<\/td>\n 5 \u00b0C \u2013 75.0 \u00b0C<\/td>\n Aparato de punto de fusi\u00f3n capilar<\/td>\n <\/tr>\n
    P\u00e9rdida por secado<\/td>\n \u2264 1.0%<\/td>\n 3%<\/td>\n 105 \u00b0C, 2 horas<\/td>\n <\/tr>\n
    Residuo en la ignici\u00f3n<\/td>\n \u2264 0.2%<\/td>\n 08%<\/td>\n Ignici\u00f3n a 600 \u00b0C<\/td>\n <\/tr>\n
    Metales pesados (como el plomo)<\/td>\n \u2264 10 ppm<\/td>\n < 5 ppm<\/td>\n ICP-MS<\/td>\n <\/tr>\n
    Ars\u00e9nico (As)<\/td>\n \u2264 2 ppm<\/td>\n < 1 ppm<\/td>\n AAS<\/td>\n <\/tr>\n
    Pruebas Microbiol\u00f3gicas<\/td>\n Recuento Total de Placas < 100 UFC\/g<\/td>\n < 10 UFC\/g<\/td>\n ISO 21149 \/ ISO 16212<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n

    \n Perfil de Solubilidad y Compatibilidad con Disolventes\n <\/h2>\n\n

    \n A diferencia de las formas de sal del \u00e1cido glicirr\u00edcico, el Glicirretinato de Estearilo es pr\u00e1cticamente insoluble en agua (9 \u03bcg\/L a 20 \u00b0C<\/span>). Requiere portadores de l\u00edpidos disueltos o disolventes org\u00e1nicos calientes.\n <\/p>\n\n

    \n \n \n \n \n \n \n \n \n \n \n
    Disolvente \/ Fase Lip\u00eddica<\/th>\n Solubilidad a 25 \u00b0C<\/th>\n Solubilidad a 75 \u00b0C<\/th>\n Nota de formulaci\u00f3n<\/th>\n <\/tr>\n <\/thead>\n
    Agua<\/td>\n Insoluble<\/td>\n Insoluble<\/td>\n No apto para fase acuosa directa<\/td>\n <\/tr>\n
    Etanol (95%)<\/td>\n Ligeramente soluble<\/td>\n Soluble (~2.5%)<\/td>\n Precipita si se enfr\u00eda r\u00e1pidamente en estado puro<\/td>\n <\/tr>\n
    Triglic\u00e9rido Capr\u00edlico\/C\u00e1prico (MCT)<\/td>\n ~0.8% p\/p<\/td>\n > 5.0% p\/p<\/td>\n Aceite portador ideal para pre-disoluci\u00f3n<\/td>\n <\/tr>\n
    Escualano<\/td>\n ~0.5% p\/p<\/td>\n > 4.0% p\/p<\/td>\n Excelente base lip\u00eddica para aceites faciales<\/td>\n <\/tr>\n
    Aceite Mineral \/ Isohexadecano<\/td>\n ~0.4% p\/p<\/td>\n ~3.5% p\/p<\/td>\n Buena compatibilidad en sistemas de hidrocarburos<\/td>\n <\/tr>\n
    Aceite de Jojoba \/ Aceites Vegetales<\/td>\n ~0.3% p\/p<\/td>\n > 3.0% p\/p<\/td>\n Requiere calentamiento por encima de 75 \u00b0C para disolver<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n

    \n Mecanismos Biol\u00f3gicos y Datos de Rendimiento In-Vitro\n <\/h2>\n\n

    \n El Glicirretinato de Estearilo modula las cascadas inflamatorias principalmente al inhibir la 11\u03b2-hidroxiesteroide deshidrogenasa tipo 1 (11\u03b2-HSD1) y las v\u00edas posteriores del \u00e1cido araquid\u00f3nico.\n <\/p>\n\n

    Inhibici\u00f3n de Mediadores Proinflamatorios<\/h3>\n

    \n Los estresores inflamatorios (radiaci\u00f3n UV, irritantes qu\u00edmicos, alteraci\u00f3n por surfactantes) activan la fosfolipasa A2. Esta enzima libera \u00e1cido araquid\u00f3nico, convirti\u00e9ndolo en prostaglandina E2 (PGE2) a trav\u00e9s de la ciclooxigenasa-2 (COX-2).\n <\/p>\n\n

    \n

    En Ensayos de Cultivo Celular HaCaT (estimulados con LPS 1 \u03bcg\/mL):<\/p>\n

      \n
    • Supresi\u00f3n de PGE2:<\/strong> Valor de IC50 de 4 \u03bcM<\/span> (vs. 28.6 \u03bcM para Glicirrizato Dipot\u00e1sico).<\/li>\n
    • Interleucina-6 (IL-6):<\/strong> Reduce la secreci\u00f3n de IL-6 en 2%<\/span> a 20 \u03bcM.<\/li>\n
    • TNF-\u03b1:<\/strong> Suprime la expresi\u00f3n en 8%<\/span> a 20 \u03bcM.<\/li>\n <\/ul>\n <\/div>\n\n

      Puntos de Referencia Antimicrobianos (Valores MIC)<\/h3>\n

      La actividad antimicrobiana de amplio espectro ayuda a estabilizar la microflora de la piel propensa al acn\u00e9 y comprometida. Las pruebas est\u00e1ndar de microdiluci\u00f3n en caldo arrojan las siguientes Concentraciones M\u00ednimas Inhibitorias (MIC):<\/p>\n

        \n
      • Cutibacterium acnes (ATCC 6919):<\/strong> MIC = 62.5 \u03bcg\/mL<\/span><\/li>\n
      • Staphylococcus aureus (ATCC 6538):<\/strong> MIC = 125 \u03bcg\/mL<\/span><\/li>\n
      • Staphylococcus epidermidis (ATCC 12228):<\/strong> MIC = 250 \u03bcg\/mL<\/span><\/li>\n <\/ul>\n\n

        Estudio de Reducci\u00f3n de Eritema In-Vivo<\/h3>\n

        \n Una prueba cl\u00ednica aleatorizada de cara dividida midi\u00f3 la reducci\u00f3n del eritema despu\u00e9s de la irritaci\u00f3n con lauril sulfato de sodio (SLS, 2%) en parche. Veinte sujetos aplicaron una formulaci\u00f3n que conten\u00eda 0.2% de Glicirretinato de Estearilo frente a un veh\u00edculo placebo dos veces al d\u00eda.\n <\/p>\n \n

        \n
          \n
        • D\u00eda 3:<\/strong> El enrojecimiento de la piel disminuy\u00f3 en 4%<\/strong> en relaci\u00f3n con la l\u00ednea de base (medido mediante el valor a* del espectrofot\u00f3metro).<\/li>\n
        • D\u00eda 7:<\/strong> El enrojecimiento disminuy\u00f3 en 9%<\/strong>, con una recuperaci\u00f3n de la P\u00e9rdida de Agua Trans-epid\u00e9rmica (TEWL) 42% m\u00e1s r\u00e1pido<\/strong> que el grupo placebo.<\/li>\n <\/ul>\n <\/div>\n\n

          \n Formulaci\u00f3n con Glicirretinato de Estearilo\n <\/h2>\n\n

          \n \u00bfPor qu\u00e9 elegir Glicirretinato de Estearilo sobre las sales tradicionales de regaliz? Altas concentraciones de sales i\u00f3nicas como el Glicirrizato Dipot\u00e1sico pueden desestabilizar los sistemas de emulsi\u00f3n o romper los espesantes polim\u00e9ricos (como Carbomer o Acrylates\/C10-30 Alkyl Acrylate Crosspolymer). El Glicirretinato de Estearilo es no i\u00f3nico y lipof\u00edlico, lo que lo hace completamente neutro para la viscosidad de la emulsi\u00f3n.\n <\/p>\n\n

          Procesamiento de Fases y Requisitos de Calentamiento<\/h3>\n
            \n
          1. A\u00f1ada el Glicirretinato de Estearilo directamente a la fase oleosa polar o de polaridad media (MCT, Benzoato de Alquilo C12-15 o Escualano).<\/li>\n
          2. Caliente la fase oleosa a 75 \u00b0C \u2013 80 \u00b0C<\/strong> bajo agitaci\u00f3n moderada hasta que el polvo se disuelva completamente en un l\u00edquido transparente.<\/li>\n
          3. Realice la emulsificaci\u00f3n con la fase acuosa a la misma temperatura.<\/li>\n
          4. Si se enfr\u00eda r\u00e1pidamente, aseg\u00farese de que la fase oleosa tenga suficientes \u00e9steres solubilizantes para evitar la recristalizaci\u00f3n por debajo de 45 \u00b0C.<\/li>\n <\/ol>\n\n

            Matriz de Dosificaci\u00f3n Sugerida<\/h3>\n
            \n \n \n \n \n \n \n \n \n \n
            Tipo de Aplicaci\u00f3n<\/th>\n Nivel de uso recomendado<\/th>\n Funci\u00f3n principal<\/th>\n <\/tr>\n <\/thead>\n
            Cremas y B\u00e1lsamos Reparadores de Barrera<\/td>\n 1% \u2013 0.5%<\/td>\n Reparaci\u00f3n, anti-enrojecimiento, reposici\u00f3n de l\u00edpidos<\/td>\n <\/tr>\n
            B\u00e1lsamos Labiales y Pintalabios<\/td>\n 2% \u2013 1.0%<\/td>\n Reparaci\u00f3n de labios agrietados, soporte antiinflamatorio<\/td>\n <\/tr>\n
            Protector Solar y Cuidado Post-Solar<\/td>\n 1% \u2013 0.3%<\/td>\n Contrarrestar el eritema inducido por UV<\/td>\n <\/tr>\n
            S\u00e9rums Anhidros y Aceites Faciales<\/td>\n 05% \u2013 0.2%<\/td>\n Calma diaria para pieles sensibles<\/td>\n <\/tr>\n
            Tratamientos para el Acn\u00e9 y las Imperfecciones<\/td>\n 2% \u2013 0.5%<\/td>\n Reducci\u00f3n de p\u00e1pulas inflamatorias localizadas<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n

            Combinaciones de Activos Sin\u00e9rgicos<\/h3>\n
              \n
            • Bissabolol (0.2%) + Glicirretinato de Estearilo (0.1%):<\/strong> Inhibici\u00f3n combinada de las v\u00edas 5-LOX y COX-2.<\/li>\n
            • Ceramida NP (0.1%) + Glicirretinato de Estearilo (0.2%):<\/strong> Reconstruye l\u00edpidos intercelulares mientras reduce la inflamaci\u00f3n subcl\u00ednica de la barrera.<\/li>\n
            • Tocoferol (0.5%) + Glicirretinato de Estearilo (0.1%):<\/strong> Protege los ingredientes activos lipof\u00edlicos de la oxidaci\u00f3n mientras previene la peroxidaci\u00f3n del escualeno en la piel.<\/li>\n <\/ul>\n\n

              \n An\u00e1lisis Comparativo: Glicirretinato de Estearilo vs. Glicirrizato Dipot\u00e1sico\n <\/h2>\n\n
              \n \n \n \n \n \n \n \n \n \n \n
              Caracter\u00edstica<\/th>\n estearilglicirretinato<\/th>\n glicirrizato dipot\u00e1sico<\/th>\n <\/tr>\n <\/thead>\n
              Solubilidad<\/td>\n Soluble en aceite \/ Lipof\u00edlico<\/td>\n Soluble en agua \/ Hidrof\u00edlico<\/td>\n <\/tr>\n
              Valor de Log P<\/td>\n 6.2<\/td>\n < -1.5<\/td>\n <\/tr>\n
              Objetivo de Penetraci\u00f3n Cut\u00e1nea<\/td>\n Estrato c\u00f3rneo y matriz lip\u00eddica<\/td>\n Espacio intercelular acuoso epid\u00e9rmico<\/td>\n <\/tr>\n
              Impacto en la Viscosidad<\/td>\n Sin efecto en la reolog\u00eda de la emulsi\u00f3n<\/td>\n Puede reducir la viscosidad del carb\u00f3mero \/ gel a > 0.5%<\/td>\n <\/tr>\n
              Estabilidad T\u00e9rmica<\/td>\n Estable hasta 85 \u00b0C en fase oleosa<\/td>\n Estable hasta 80 \u00b0C en fase acuosa<\/td>\n <\/tr>\n
              Formato de Producto Ideal<\/td>\n Barras de labios, cremas ricas, aceites, protectores solares<\/td>\n T\u00f3nicos, geles, mascarillas de l\u00e1mina, s\u00e9rums acuosos<\/td>\n <\/tr>\n <\/tbody>\n <\/table>\n <\/div>\n\n

              \n Estatus Regulatorio y Evaluaci\u00f3n de Seguridad\n <\/h2>\n\n
                \n
              • CIR de EE. UU. (Cosmetic Ingredient Review):<\/strong> Evaluado como seguro para su uso en formulaciones cosm\u00e9ticas hasta 1.0%<\/span>.<\/li>\n
              • UE SCCS \/ CosIng:<\/strong> Listado sin restricci\u00f3n espec\u00edfica (Ref No: 38334); se aplican los l\u00edmites est\u00e1ndar de seguridad cosm\u00e9tica.<\/li>\n
              • NMPA de China (IECIC):<\/strong> Incluido en el Inventario de Ingredientes Cosm\u00e9ticos Existentes en China.<\/li>\n
              • Jap\u00f3n (F\u00e1rmaco Cuasi-Medicinal Activo):<\/strong> Aprobado como ingrediente activo para reclamos antiinflamatorios y calmantes dentro de l\u00edmites especificados (1% \u2013 0.5%<\/span>).<\/li>\n <\/ul>\n\n

                \n Los estudios de fototoxicidad y sensibilizaci\u00f3n confirman que el Estearil Glicirretinato exhibe un potencial fotot\u00f3xico cero a una concentraci\u00f3n de 1.0%. Supera las pruebas est\u00e1ndar de parches repetidos en humanos (HRIPT) sin irritaci\u00f3n observada.\n <\/p>\n\n

                \n Empaque, Almacenamiento y Manipulaci\u00f3n\n <\/h2>\n\n
                  \n
                • Embalaje:<\/strong> El suministro industrial est\u00e1ndar se presenta en bolsas de papel de aluminio o tambores de fibra revestidos con bolsas de polietileno de doble capa.<\/li>\n
                • Condiciones de almacenamiento:<\/strong> Mantenga los recipientes bien cerrados en un lugar fresco, seco y ventilado (15 \u00b0C \u2013 25 \u00b0C). Proteger de la luz solar directa y la humedad.<\/li>\n
                • Duraci\u00f3n:<\/strong> 24 meses a partir de la fecha de fabricaci\u00f3n cuando se almacena en envases originales sin abrir.<\/li>\n
                • Solicitudes de Muestras:<\/strong> Las muestras de producci\u00f3n de grado puro est\u00e1n disponibles para investigaci\u00f3n y ensayos de formulaci\u00f3n de I+D bajo pedido.<\/li>\n <\/ul>\n\n
                  \n\n

                  \n Literatura y Referencias Cient\u00edficas\n <\/h2>\n\n
                    \n
                  1. Panel de Expertos de Cosmetic Ingredient Review. (2007). Informe Final sobre la Evaluaci\u00f3n de Seguridad del \u00c1cido Glicirret\u00ednico, sus Sales y \u00c9steres<\/em>International Journal of Toxicology, 26(Suppl 2), 79\u2013112.<\/li>\n
                  2. Shibata, S. (2000). Una revisi\u00f3n de las acciones antiinflamatorias del regaliz y sus compuestos activos<\/em>Journal of the Pharmaceutical Society of Japan, 120(10), 849\u2013862.<\/li>\n
                  3. Finney, R. S. H., & Somers, G. F. (1958). La actividad antiinflamatoria del \u00e1cido glicirret\u00ednico y sus derivados<\/em>Journal of Pharmacy and Pharmacology, 10(1), 613\u2013620.<\/li>\n
                  4. Yokota, T., Nishio, H., Kubota, Y., & Mizoguchi, M. (1998). El efecto inhibidor del extracto de regaliz en la melanog\u00e9nesis y la inflamaci\u00f3n<\/em>Pigment Cell Research, 11(6), 355\u2013361.<\/li>\n
                  5. Inagaki, N., et al. (2006). Efectos inhibidores de derivados del \u00e1cido 18\u03b2-glicirret\u00ednico sobre reacciones de hipersensibilidad inmediata y retardada<\/em>Biological and Pharmaceutical Bulletin, 29(8), 1734\u20131739.<\/li>\n <\/ol>\n\n<\/div>","protected":false},"excerpt":{"rendered":"

                    Estearil Glicirretinato es el \u00e9ster lipof\u00edlico derivado del \u00e1cido 18\u03b2-glicirret\u00ednico y alcohol estear\u00edlico. Mientras que los extractos de regaliz solubles en agua como el Dipotasio Glicirrizato dominan los sueros acuosos, luchan\u2026<\/p>","protected":false},"author":8,"featured_media":5752,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[60],"tags":[],"class_list":["post-15458","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-product-news"],"yoast_head":"\nWhat Is Stearyl Glycyrrhetinate? Technical Brief, Anti-Inflammatory Data, and Formulating Oil-Soluble Licorice Derivatives - Huatai Bio<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/glabridin.net\/es\/what-is-stearyl-glycyrrhetinate-technical-brief-anti-inflammatory-data-and-formulating-oil-soluble-licorice-derivatives\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What Is Stearyl Glycyrrhetinate? Technical Brief, Anti-Inflammatory Data, and Formulating Oil-Soluble Licorice Derivatives\" \/>\n<meta property=\"og:description\" content=\"Stearyl Glycyrrhetinate is the lipophilic ester derived from 18β-glycyrrhetinic acid and stearyl alcohol. 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